Associated Genetic Biomarkers
EGFR S464L is present in 0.01% of AACR GENIE cases, with unknown having the greatest prevalence .
EGFR S464L serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains EGFR S464L as an inclusion criterion, 1 is phase 2 (1 open).
Trials with EGFR S464L in the inclusion eligibility criteria most commonly target colorectal adenocarcinoma .
Panitumumab is the most frequent therapy in trials with EGFR S464L as an inclusion criteria .
Significance of EGFR S464L in Diseases
Colorectal Adenocarcinoma +
EGFR is altered in 3.25% of colorectal adenocarcinoma patients .
EGFR S464L is an inclusion criterion in 1 clinical trial for colorectal adenocarcinoma, of which 1 is open and 0 are closed. Of the trial that contains EGFR S464L and colorectal adenocarcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.