Associated Genetic Biomarkers
ERBB2 D769H is present in 0.03% of AACR GENIE cases, with bladder carcinoma, breast carcinoma, uterine corpus neoplasm, adenocarcinoma of the gastroesophageal junction, and cervical neoplasm having the greatest prevalence .
ERBB2 D769H serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 D769H as an inclusion criterion, 1 is phase 2 (1 open).
Trials with ERBB2 D769H in the inclusion eligibility criteria most commonly target breast carcinoma .
Neratinib is the most frequent therapy in trials with ERBB2 D769H as an inclusion criteria .
Significance of ERBB2 D769H in Diseases
Breast Carcinoma +
ERBB2 is mutated in 14.05% of breast carcinoma patients with ERBB2 D769H present in 0.02% of all breast carcinoma patients .
ERBB2 D769H is an inclusion criterion in 1 clinical trial for breast carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 D769H and breast carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Neratinib is the most frequent therapy in trials for breast carcinoma that contain ERBB2 D769H .
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