ERBB2 Exon 20 Mutation
Associated Genetic Biomarkers
ERBB2 Exon 20 Mutation is present in 0.49% of AACR GENIE cases, with lung adenocarcinoma, breast invasive ductal carcinoma, breast invasive lobular carcinoma, colon adenocarcinoma, and invasive breast carcinoma having the greatest prevalence .
ERBB2 Exon 20 Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 Exon 20 Mutation as an inclusion criterion, 1 is phase 2 (1 open).
Trials with ERBB2 Exon 20 Mutation in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma .
Docetaxel, pertuzumab, and trastuzumab are the most frequent therapies in trials with ERBB2 Exon 20 Mutation as an inclusion criteria .
Significance of ERBB2 Exon 20 Mutation in Diseases
Non-Small Cell Lung Carcinoma +
ERBB2 is altered in 3.65% of non-small cell lung carcinoma patients with ERBB2 Exon 20 Mutation present in 1.46% of all non-small cell lung carcinoma patients .
ERBB2 Exon 20 Mutation is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 Exon 20 Mutation and non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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