Associated Genetic Biomarkers
ERBB2 G776delinsVC is present in 0.02% of AACR GENIE cases, with lung adenocarcinoma having the greatest prevalence .
ERBB2 G776delinsVC serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain ERBB2 G776delinsVC as an inclusion criterion, 1 is phase 1/phase 2 (1 open) and 1 is phase 2 (1 open).
Trials with ERBB2 G776delinsVC in the inclusion eligibility criteria most commonly target malignant solid tumor and non-small cell lung carcinoma .
Bdtx-189, docetaxel, pertuzumab, and trastuzumab are the most frequent therapies in trials with ERBB2 G776delinsVC as an inclusion criteria .
Significance of ERBB2 G776delinsVC in Diseases
Non-Small Cell Lung Carcinoma +
ERBB2 is altered in 3.65% of non-small cell lung carcinoma patients with ERBB2 G776delinsVC present in 0.13% of all non-small cell lung carcinoma patients .
ERBB2 G776delinsVC is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 G776delinsVC and non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Malignant Solid Tumor +
ERBB2 is altered in 4.96% of malignant solid tumor patients with ERBB2 G776delinsVC present in 0.02% of all malignant solid tumor patients .
ERBB2 G776delinsVC is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 G776delinsVC and malignant solid tumor as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.