Associated Genetic Biomarkers
ERBB2 L755S is present in 0.17% of AACR GENIE cases, with breast carcinoma, uterine corpus neoplasm, bladder carcinoma, colorectal adenocarcinoma, and adenocarcinoma of unknown primary having the greatest prevalence .
ERBB2 L755S is a predictive biomarker for use of trastuzumab emtansine in patients.
There are 1 NCCN guidelines that support the use of a targeted therapy based on the presence of ERBB2 L755S.
Non-small cell lung carcinoma has the most therapies targeted against ERBB2 L755S or its related pathways .
Trastuzumab Emtansine +
Non-Small Cell Lung Carcinoma -
|Biomarker Criteria:||Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Metastatic (NCCN)|
|Note: Emerging Targeted Agent for patients with HER2 mutations, per NCCN.|
ERBB2 L755S serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain ERBB2 L755S as an inclusion criterion, 2 are phase 2 (2 open).
Trials with ERBB2 L755S in the inclusion eligibility criteria most commonly target breast carcinoma and non-small cell lung carcinoma .
Docetaxel, neratinib, pertuzumab, and trastuzumab are the most frequent therapies in trials with ERBB2 L755S as an inclusion criteria .
Significance of ERBB2 L755S in Diseases
Non-Small Cell Lung Carcinoma +
ERBB2 is mutated in 4.12% of non-small cell lung carcinoma patients .
ERBB2 L755S is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 L755S and non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Trastuzumab emtansine is currently approved for use in patients with ERBB2 L755S in non-small cell lung carcinoma .
Docetaxel, pertuzumab, and trastuzumab are the most frequent therapies in trials for non-small cell lung carcinoma that contain ERBB2 L755S .
Breast Carcinoma +
ERBB2 is mutated in 14.05% of breast carcinoma patients with ERBB2 L755S present in 0.74% of all breast carcinoma patients .
ERBB2 L755S is an inclusion criterion in 1 clinical trial for breast carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 L755S and breast carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Neratinib is the most frequent therapy in trials for breast carcinoma that contain ERBB2 L755S .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.