Associated Genetic Biomarkers
ERBB2 S653C is present in 0.01% of AACR GENIE cases, with bladder signet ring cell adenocarcinoma, bladder urothelial carcinoma, and breast invasive lobular carcinoma having the greatest prevalence .
ERBB2 S653C serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 S653C as an inclusion criterion, 1 is phase 1/phase 2 (1 open).
Trials with ERBB2 S653C in the inclusion eligibility criteria most commonly target malignant solid tumor .
Bdtx-189 is the most frequent therapy in trials with ERBB2 S653C as an inclusion criteria .
Significance of ERBB2 S653C in Diseases
Malignant Solid Tumor +
ERBB2 is altered in 5.44% of malignant solid tumor patients with ERBB2 S653C present in 0.0% of all malignant solid tumor patients .
ERBB2 S653C is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 S653C and malignant solid tumor as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
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