Associated Genetic Biomarkers
ERBB2 T862A is a predictive biomarker for use of ado-trastuzumab emtansine in patients.
Of the therapies with ERBB2 T862A as a predictive biomarker, 1 has NCCN guidelines in at least one clinical setting.
Non-small cell lung carcinoma has the most therapies targeted against ERBB2 T862A or its related pathways .
Ado-Trastuzumab Emtansine +
Non-Small Cell Lung Carcinoma -
|Biomarker Criteria:||Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Metastatic (NCCN)|
|Note: Emerging Targeted Agent for patients with HER2 mutations, per NCCN.|
ERBB2 T862A serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 T862A as an inclusion criterion, 1 is phase 1/phase 2 (1 open).
Trials with ERBB2 T862A in the inclusion eligibility criteria most commonly target malignant solid tumor .
Bdtx-189 is the most frequent therapy in trials with ERBB2 T862A as an inclusion criteria .
Significance of ERBB2 T862A in Diseases
Non-Small Cell Lung Carcinoma +
Malignant Solid Tumor +
ERBB2 is altered in 4.96% of malignant solid tumor patients with ERBB2 T862A present in 0.02% of all malignant solid tumor patients .
ERBB2 T862A is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 T862A and malignant solid tumor as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
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