Associated Genetic Biomarkers
ERBB2 V777L is present in 0.14% of AACR GENIE cases, with breast carcinoma, colorectal adenocarcinoma, duodenal adenocarcinoma, head and neck cancer, and esophageal cancer having the greatest prevalence .
ERBB2 V777L is a predictive biomarker for use of trastuzumab emtansine in patients.
There are 1 NCCN guidelines that support the use of a targeted therapy based on the presence of ERBB2 V777L.
Non-small cell lung carcinoma has the most therapies targeted against ERBB2 V777L or its related pathways .
Trastuzumab Emtansine +
Non-Small Cell Lung Carcinoma -
|Biomarker Criteria:||Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Metastatic (NCCN)|
|Note: Emerging Targeted Agent for patients with HER2 mutations, per NCCN.|
ERBB2 V777L serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 V777L as an inclusion criterion, 1 is phase 2 (1 open).
Trials with ERBB2 V777L in the inclusion eligibility criteria most commonly target breast carcinoma .
Neratinib is the most frequent therapy in trials with ERBB2 V777L as an inclusion criteria .
Significance of ERBB2 V777L in Diseases
Non-Small Cell Lung Carcinoma +
Breast Carcinoma +
ERBB2 is mutated in 14.05% of breast carcinoma patients with ERBB2 V777L present in 0.41% of all breast carcinoma patients .
ERBB2 V777L is an inclusion criterion in 1 clinical trial for breast carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 V777L and breast carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Neratinib is the most frequent therapy in trials for breast carcinoma that contain ERBB2 V777L .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.
Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.