Associated Genetic Biomarkers
ERBB4 Fusion is present in 0.04% of AACR GENIE cases, with breast invasive ductal carcinoma, colon adenocarcinoma, acute myeloid leukemia, bladder urothelial carcinoma, and conventional glioblastoma multiforme having the greatest prevalence .
ERBB4 Fusion serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ERBB4 Fusion as an inclusion criterion, 1 is phase 2 (1 open).
Trials with ERBB4 Fusion in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma .
Tarloxotinib is the most frequent therapy in trials with ERBB4 Fusion as an inclusion criteria .
Significance of ERBB4 Fusion in Diseases
Malignant Solid Tumor +
ERBB4 Fusion is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains ERBB4 Fusion and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
Non-Small Cell Lung Carcinoma +
ERBB4 Fusion is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB4 Fusion and non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.