Associated Genetic Biomarkers
ERCC1 Mutation is present in 0.54% of AACR GENIE cases, with colon adenocarcinoma, conventional glioblastoma multiforme, endometrial endometrioid adenocarcinoma, high grade ovarian serous adenocarcinoma, and lung adenocarcinoma having the greatest prevalence .
ERCC1 Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ERCC1 Mutation as an inclusion criterion, 1 is phase 2 (1 open).
Trials with ERCC1 Mutation in the inclusion eligibility criteria most commonly target malignant solid tumor .
Temozolomide and veliparib are the most frequent therapies in trials with ERCC1 Mutation as an inclusion criteria .
Significance of ERCC1 Mutation in Diseases
Malignant Solid Tumor +
ERCC1 is altered in 0.23% of malignant solid tumor patients with ERCC1 Mutation present in 0.58% of all malignant solid tumor patients .
ERCC1 Mutation is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains ERCC1 Mutation and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
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