Associated Genetic Biomarkers
ESR1 Mutation is present in 2.08% of AACR GENIE cases, with breast invasive ductal carcinoma, invasive breast carcinoma, colon adenocarcinoma, lung adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence .
ESR1 Mutation serves as an inclusion eligibility criterion in 6 clinical trials, of which 5 are open and 1 is closed. Of the trials that contain ESR1 Mutation as an inclusion criterion, 1 is early phase 1 (1 open), 1 is phase 1/phase 2 (0 open), 3 are phase 2 (3 open), and 1 is phase 3 (1 open).
Trials with ESR1 Mutation in the inclusion eligibility criteria most commonly target breast carcinoma and breast adenocarcinoma .
Fulvestrant, tamoxifen, azd9833, abemaciclib, and anastrozole are the most frequent therapies in trials with ESR1 Mutation as an inclusion criteria .
Significance of ESR1 Mutation in Diseases
Breast Carcinoma +
ESR1 is altered in 8.37% of breast carcinoma patients with ESR1 Mutation present in 6.9% of all breast carcinoma patients .
ESR1 Mutation is an inclusion criterion in 5 clinical trials for breast carcinoma, of which 4 are open and 1 is closed. Of the trials that contain ESR1 Mutation and breast carcinoma as inclusion criteria, 1 is early phase 1 (1 open), 1 is phase 1/phase 2 (0 open), and 3 are phase 2 (3 open) .
Breast Adenocarcinoma +
ESR1 is altered in 7.13% of breast adenocarcinoma patients with ESR1 Mutation present in 5.77% of all breast adenocarcinoma patients .
ESR1 Mutation is an inclusion criterion in 1 clinical trial for breast adenocarcinoma, of which 1 is open and 0 are closed. Of the trial that contains ESR1 Mutation and breast adenocarcinoma as inclusion criteria, 1 is phase 3 (1 open) .
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