Associated Genetic Biomarkers
EZH2 Amplification is present in 0.15% of AACR GENIE cases, with lung adenocarcinoma, breast invasive ductal carcinoma, cutaneous melanoma, prostate adenocarcinoma, and melanoma of unknown primary having the greatest prevalence .
EZH2 Amplification serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains EZH2 Amplification as an inclusion criterion, 1 is phase 2 (1 open).
Trials with EZH2 Amplification in the inclusion eligibility criteria most commonly target malignant solid tumor and non-hodgkin lymphoma .
Tazemetostat is the most frequent therapy in trials with EZH2 Amplification as an inclusion criteria .
Significance of EZH2 Amplification in Diseases
Malignant Solid Tumor +
EZH2 is altered in 1.19% of malignant solid tumor patients with EZH2 Amplification present in 0.16% of all malignant solid tumor patients .
EZH2 Amplification is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains EZH2 Amplification and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
Non-Hodgkin Lymphoma +
EZH2 is altered in 8.7% of non-hodgkin lymphoma patients with EZH2 Amplification present in 0.14% of all non-hodgkin lymphoma patients .
EZH2 Amplification is an inclusion criterion in 1 clinical trial for non-hodgkin lymphoma, of which 1 is open and 0 are closed. Of the trial that contains EZH2 Amplification and non-hodgkin lymphoma as inclusion criteria, 1 is phase 2 (1 open) .
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