Associated Genetic Biomarkers
EZH2 Y646S is a predictive biomarker for use of tazemetostat in patients.
Of the therapies with EZH2 Y646S as a predictive biomarker, 1 is FDA-approved in at least one clinical setting.
Follicular lymphoma has the most therapies targeted against EZH2 Y646S or its related pathways .
Follicular Lymphoma -
|Biomarker Criteria:||Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Refractory (FDA), Relapse (FDA)|
|Note: Indicated for adult patients with relapsed or refractory follicular lymphoma whose tumors are positive for an EZH2 mutation and who have received at least 2 prior systemic therapies.|
Significance of EZH2 Y646S in Diseases
Follicular Lymphoma +
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