Associated Genetic Biomarkers
FAN1 Mutation is present in 2.05% of AACR GENIE cases, with colon adenocarcinoma, lung adenocarcinoma, melanoma, endometrial endometrioid adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence .
FAN1 Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains FAN1 Mutation as an inclusion criterion, 1 is phase 2 (1 open).
Trials with FAN1 Mutation in the inclusion eligibility criteria most commonly target breast carcinoma .
Durvalumab, fulvestrant, and olaparib are the most frequent therapies in trials with FAN1 Mutation as an inclusion criteria .
Significance of FAN1 Mutation in Diseases
Breast Carcinoma +
FAN1 is altered in 1.37% of breast carcinoma patients with FAN1 Mutation present in 1.23% of all breast carcinoma patients .
FAN1 Mutation is an inclusion criterion in 1 clinical trial for breast carcinoma, of which 1 is open and 0 are closed. Of the trial that contains FAN1 Mutation and breast carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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