Associated Genetic Biomarkers
FANCE Deletion is present in 0.04% of AACR GENIE cases, with breast carcinoma, adenocarcinoma of unknown primary, cervical neoplasm, lymphoma, and renal cell carcinoma having the greatest prevalence .
FANCE Deletion serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain FANCE Deletion as an inclusion criterion, 2 are phase 2 (2 open).
Trials with FANCE Deletion in the inclusion eligibility criteria most commonly target breast carcinoma and urothelial carcinoma .
Olaparib is the most frequent therapy in trials with FANCE Deletion as an inclusion criteria .
Significance of FANCE Deletion in Diseases
Breast Carcinoma +
FANCE is mutated in 1.13% of breast carcinoma patients with FANCE Deletion present in 0.16% of all breast carcinoma patients .
FANCE Deletion is an inclusion criterion in 1 clinical trial for breast carcinoma, of which 1 is open and 0 are closed. Of the trial that contains FANCE Deletion and breast carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Olaparib is the most frequent therapy in trials for breast carcinoma that contain FANCE Deletion .
Urothelial Carcinoma +
FANCE is mutated in 2.15% of urothelial carcinoma patients .
FANCE Deletion is an inclusion criterion in 1 clinical trial for urothelial carcinoma, of which 1 is open and 0 are closed. Of the trial that contains FANCE Deletion and urothelial carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Olaparib is the most frequent therapy in trials for urothelial carcinoma that contain FANCE Deletion .
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