Associated Genetic Biomarkers
FH Mutation is present in 0.77% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence .
FH Mutation serves as an inclusion eligibility criterion in 4 clinical trials, of which 3 are open and 1 is closed. Of the trials that contain FH Mutation as an inclusion criterion, 1 is phase 1/phase 2 (0 open) and 3 are phase 2 (3 open).
Trials with FH Mutation in the inclusion eligibility criteria most commonly target renal cell carcinoma .
Sintilimab, avelumab, axitinib, metformin, and talazoparib are the most frequent therapies in trials with FH Mutation as an inclusion criteria .
Significance of FH Mutation in Diseases
Renal Cell Carcinoma +
FH is altered in 1.79% of renal cell carcinoma patients with FH Mutation present in 1.54% of all renal cell carcinoma patients .
FH Mutation is an inclusion criterion in 4 clinical trials for renal cell carcinoma, of which 3 are open and 1 is closed. Of the trials that contain FH Mutation and renal cell carcinoma as inclusion criteria, 1 is phase 1/phase 2 (0 open) and 3 are phase 2 (3 open) .
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