Associated Genetic Biomarkers
H3F3A Loss is present in 0.02% of AACR GENIE cases, with conventional glioblastoma multiforme, cutaneous melanoma, dedifferentiated liposarcoma, desmoplastic small round cell tumor, and esophageal adenocarcinoma having the greatest prevalence .
H3F3A Loss serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains H3F3A Loss as an inclusion criterion, 1 is phase 2 (1 open).
Trials with H3F3A Loss in the inclusion eligibility criteria most commonly target malignant peripheral nerve sheath tumor .
Decitabine and cedazuridine is the most frequent therapy in trials with H3F3A Loss as an inclusion criteria .
Significance of H3F3A Loss in Diseases
Malignant Peripheral Nerve Sheath Tumor +
H3F3A Loss is an inclusion criterion in 1 clinical trial for malignant peripheral nerve sheath tumor, of which 1 is open and 0 are closed. Of the trial that contains H3F3A Loss and malignant peripheral nerve sheath tumor as inclusion criteria, 1 is phase 2 (1 open) .
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