Associated Genetic Biomarkers
IDH2 R172T is present in 0.01% of AACR GENIE cases, with chondrosarcoma, follicular dendritic cell sarcoma, head and neck carcinoma, lung adenocarcinoma, and sinonasal undifferentiated carcinoma having the greatest prevalence .
IDH2 R172T is a predictive biomarker for use of enasidenib in patients.
Of the therapies with IDH2 R172T as a predictive biomarker, 1 is FDA-approved and 1 has NCCN guidelines in at least one clinical setting.
Acute myeloid leukemia has the most therapies targeted against IDH2 R172T or its related pathways .
Acute Myeloid Leukemia -
|Biomarker Criteria:||Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Refractory (FDA, NCCN), Relapse (FDA, NCCN)|
|Note: Enasidenib is an IDH2 inhibitor approved by the FDA for treatment of adult patients with relapsed or refractory AML with an IDH2 mutation.|
Significance of IDH2 R172T in Diseases
Acute Myeloid Leukemia +
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