Associated Genetic Biomarkers
IDH2 R172T is a predictive biomarker for use of enasidenib in patients.
Of the therapies with IDH2 R172T as a predictive biomarker, 1 is FDA-approved and 1 has NCCN guidelines in at least one clinical setting.
Acute myeloid leukemia has the most therapies targeted against IDH2 R172T or its related pathways .
Acute Myeloid Leukemia -
|Biomarker Criteria:||Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Refractory (FDA, NCCN), Relapse (FDA, NCCN)|
|Note: Enasidenib is an IDH2 inhibitor approved by the FDA for treatment of adult patients with relapsed or refractory AML with an IDH2 mutation.|
IDH2 R172T serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains IDH2 R172T as an inclusion criterion, 1 is phase 1 (1 open).
Trials with IDH2 R172T in the inclusion eligibility criteria most commonly target anaplastic astrocytoma and diffuse astrocytoma .
Radiation therapy, telaglenastat, and temozolomide are the most frequent therapies in trials with IDH2 R172T as an inclusion criteria .
Significance of IDH2 R172T in Diseases
Acute Myeloid Leukemia +
Anaplastic Astrocytoma +
IDH2 is altered in 1.83% of anaplastic astrocytoma patients .
IDH2 R172T is an inclusion criterion in 1 clinical trial for anaplastic astrocytoma, of which 1 is open and 0 are closed. Of the trial that contains IDH2 R172T and anaplastic astrocytoma as inclusion criteria, 1 is phase 1 (1 open) .
Diffuse Astrocytoma +
IDH2 R172T is an inclusion criterion in 1 clinical trial for diffuse astrocytoma, of which 1 is open and 0 are closed. Of the trial that contains IDH2 R172T and diffuse astrocytoma as inclusion criteria, 1 is phase 1 (1 open) .
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