Associated Genetic Biomarkers
JAK2 R683S is present in 0.03% of AACR GENIE cases, with B-cell lymphoblastic leukemia/lymphoma having the greatest prevalence .
JAK2 R683S serves as an inclusion eligibility criterion in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains JAK2 R683S as an inclusion criterion, 1 is phase 1 (0 open).
Significance of JAK2 R683S in Diseases
Myelodysplastic Syndromes +
JAK2 is altered in 3.49% of myelodysplastic syndromes patients .
JAK2 R683S is an inclusion criterion in 1 clinical trial for myelodysplastic syndromes, of which 0 are open and 1 is closed. Of the trial that contains JAK2 R683S and myelodysplastic syndromes as inclusion criteria, 1 is phase 1 (0 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.