Associated Genetic Biomarkers
KIT A829P is present in 0.02% of AACR GENIE cases, with gastrointestinal stromal tumor, acral lentiginous melanoma, melanoma, mucosal melanoma of the urethra, and seminoma having the greatest prevalence .
KIT A829P is a predictive biomarker for use of imatinib and sunitinib in patients.
Melanoma has the most therapies targeted against KIT A829P or its related pathways .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.