KIT Expression is a predictive biomarker for use of imatinib in patients.
Of the therapies with KIT Expression as a predictive biomarker, 1 is FDA-approved in at least one clinical setting.
Gastrointestinal stromal tumor has the most therapies targeted against KIT Expression or its related pathways .
Gastrointestinal Stromal Tumor -
Sample must match one or more of the following:
|Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Metastatic (FDA)|
|Note: Imatinib is indicated for patients with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST).|
KIT Expression serves as an inclusion eligibility criterion in 15 clinical trials, of which 13 are open and 2 are closed. Of the trials that contain KIT Expression as an inclusion criterion, 2 are phase 1 (1 open), 1 is phase 1/phase 2 (1 open), 8 are phase 2 (8 open), and 4 are phase 3 (3 open).
Trials with KIT Expression in the inclusion eligibility criteria most commonly target gastrointestinal stromal tumor, acute myeloid leukemia, and myelodysplastic syndromes .
Imatinib, donor-derived wt1/prame/ny-eso-1/survivin-specific t-lymphocytes, avelumab, axitinib, and azacitidine are the most frequent therapies in trials with KIT Expression as an inclusion criteria .
Significance of KIT Expression in Diseases
Gastrointestinal Stromal Tumor +
KIT is altered in 58.64% of gastrointestinal stromal tumor patients .
KIT Expression is an inclusion criterion in 11 clinical trials for gastrointestinal stromal tumor, of which 10 are open and 1 is closed. Of the trials that contain KIT Expression and gastrointestinal stromal tumor as inclusion criteria, 1 is phase 1/phase 2 (1 open), 6 are phase 2 (6 open), and 4 are phase 3 (3 open) .
Imatinib has evidence of efficacy in patients with KIT Expression in gastrointestinal stromal tumor .
Acute Myeloid Leukemia +
KIT is altered in 2.14% of acute myeloid leukemia patients .
KIT Expression is an inclusion criterion in 3 clinical trials for acute myeloid leukemia, of which 3 are open and 0 are closed. Of the trials that contain KIT Expression and acute myeloid leukemia as inclusion criteria, 1 is phase 1 (1 open) and 2 are phase 2 (2 open) .
Myelodysplastic Syndromes +
KIT is altered in 1.91% of myelodysplastic syndromes patients .
KIT Expression is an inclusion criterion in 2 clinical trials for myelodysplastic syndromes, of which 2 are open and 0 are closed. Of the trials that contain KIT Expression and myelodysplastic syndromes as inclusion criteria, 1 is phase 1 (1 open) and 1 is phase 2 (1 open) .
Malignant Solid Tumor +
KIT is altered in 2.68% of malignant solid tumor patients .
KIT Expression is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 0 are open and 1 is closed. Of the trial that contains KIT Expression and malignant solid tumor as inclusion criteria, 1 is phase 1 (0 open) .
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