Associated Genetic Biomarkers
KMT2A Insertion is present in 0.02% of AACR GENIE cases, with breast carcinoma, malignant glioma, colorectal adenocarcinoma, non-small cell lung carcinoma, and ovarian neoplasm having the greatest prevalence .
KMT2A Insertion serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains KMT2A Insertion as an inclusion criterion, 1 is phase 1 (1 open).
Trials with KMT2A Insertion in the inclusion eligibility criteria most commonly target acute myeloid leukemia .
Azacitidine and nintedanib are the most frequent therapies in trials with KMT2A Insertion as an inclusion criteria .
Significance of KMT2A Insertion in Diseases
Acute Myeloid Leukemia +
KMT2A is mutated in 1.44% of acute myeloid leukemia patients .
KMT2A Insertion is an inclusion criterion in 1 clinical trial for acute myeloid leukemia, of which 1 is open and 0 are closed. Of the trial that contains KMT2A Insertion and acute myeloid leukemia as inclusion criteria, 1 is phase 1 (1 open) .
Azacitidine and nintedanib are the most frequent therapies in trials for acute myeloid leukemia that contain KMT2A Insertion .
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