Associated Genetic Biomarkers
MDC1 Mutation is present in 1.54% of AACR GENIE cases, with lung adenocarcinoma, cutaneous melanoma, colon adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence .
MDC1 Mutation serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain MDC1 Mutation as an inclusion criterion, 2 are phase 2 (2 open).
Trials with MDC1 Mutation in the inclusion eligibility criteria most commonly target melanoma and urothelial carcinoma .
Nivolumab, olaparib, and talazoparib are the most frequent therapies in trials with MDC1 Mutation as an inclusion criteria .
Significance of MDC1 Mutation in Diseases
MDC1 is altered in 7.46% of melanoma patients with MDC1 Mutation present in 6.74% of all melanoma patients .
MDC1 Mutation is an inclusion criterion in 1 clinical trial for melanoma, of which 1 is open and 0 are closed. Of the trial that contains MDC1 Mutation and melanoma as inclusion criteria, 1 is phase 2 (1 open) .
Urothelial Carcinoma +
MDC1 is altered in 4.95% of urothelial carcinoma patients with MDC1 Mutation present in 4.82% of all urothelial carcinoma patients .
MDC1 Mutation is an inclusion criterion in 1 clinical trial for urothelial carcinoma, of which 1 is open and 0 are closed. Of the trial that contains MDC1 Mutation and urothelial carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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