Associated Genetic Biomarkers
MECOM Fusion is present in 0.05% of AACR GENIE cases, with esophageal adenocarcinoma, bladder urothelial carcinoma, colon adenocarcinoma, high grade ovarian serous adenocarcinoma, and adenocarcinoma of the gastroesophageal junction having the greatest prevalence .
MECOM Fusion serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains MECOM Fusion as an inclusion criterion, 1 is phase 2 (1 open).
Trials with MECOM Fusion in the inclusion eligibility criteria most commonly target acute myeloid leukemia and myelodysplastic syndromes .
Donor lymphocytes and guadecitabine are the most frequent therapies in trials with MECOM Fusion as an inclusion criteria .
Significance of MECOM Fusion in Diseases
Acute Myeloid Leukemia +
MECOM Fusion is an inclusion criterion in 1 clinical trial for acute myeloid leukemia, of which 1 is open and 0 are closed. Of the trial that contains MECOM Fusion and acute myeloid leukemia as inclusion criteria, 1 is phase 2 (1 open) .
Myelodysplastic Syndromes +
MECOM Fusion is an inclusion criterion in 1 clinical trial for myelodysplastic syndromes, of which 1 is open and 0 are closed. Of the trial that contains MECOM Fusion and myelodysplastic syndromes as inclusion criteria, 1 is phase 2 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.