MET Exon 14 Mutation
Associated Genetic Biomarkers
MET Exon 14 Mutation is present in 0.18% of AACR GENIE cases, with lung adenocarcinoma, cutaneous melanoma, and squamous cell lung carcinoma having the greatest prevalence .
MET Exon 14 Mutation serves as an inclusion eligibility criterion in 4 clinical trials, of which 4 are open and 0 are closed. Of the trials that contain MET Exon 14 Mutation as an inclusion criterion, 1 is phase 1/phase 2 (1 open) and 3 are phase 2 (3 open).
Trials with MET Exon 14 Mutation in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma .
Crizotinib, regn5093, and merestinib are the most frequent therapies in trials with MET Exon 14 Mutation as an inclusion criteria .
Significance of MET Exon 14 Mutation in Diseases
Non-Small Cell Lung Carcinoma +
MET is altered in 3.81% of non-small cell lung carcinoma patients with MET Exon 14 Mutation present in 0.78% of all non-small cell lung carcinoma patients .
MET Exon 14 Mutation is an inclusion criterion in 4 clinical trials for non-small cell lung carcinoma, of which 4 are open and 0 are closed. Of the trials that contain MET Exon 14 Mutation and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1/phase 2 (1 open) and 3 are phase 2 (3 open) .
Malignant Solid Tumor +
MET is altered in 2.28% of malignant solid tumor patients with MET Exon 14 Mutation present in 0.19% of all malignant solid tumor patients .
MET Exon 14 Mutation is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains MET Exon 14 Mutation and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.
Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.