MET Exon 14 Mutation
Associated Genetic Biomarkers
MET Exon 14 Mutation is present in 0.23% of AACR GENIE cases, with lung adenocarcinoma, cutaneous melanoma, melanoma, squamous cell lung carcinoma, and lung pleomorphic carcinoma having the greatest prevalence .
MET Exon 14 Mutation serves as an inclusion eligibility criterion in 3 clinical trials, of which 3 are open and 0 are closed. Of the trials that contain MET Exon 14 Mutation as an inclusion criterion, 1 is phase 1/phase 2 (1 open) and 2 are phase 2 (2 open).
Trials with MET Exon 14 Mutation in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma .
Regn5093, crizotinib, and merestinib are the most frequent therapies in trials with MET Exon 14 Mutation as an inclusion criteria .
Significance of MET Exon 14 Mutation in Diseases
Non-Small Cell Lung Carcinoma +
MET is altered in 5.01% of non-small cell lung carcinoma patients with MET Exon 14 Mutation present in 0.89% of all non-small cell lung carcinoma patients .
MET Exon 14 Mutation is an inclusion criterion in 3 clinical trials for non-small cell lung carcinoma, of which 3 are open and 0 are closed. Of the trials that contain MET Exon 14 Mutation and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1/phase 2 (1 open) and 2 are phase 2 (2 open) .
Malignant Solid Tumor +
MET is altered in 2.83% of malignant solid tumor patients with MET Exon 14 Mutation present in 0.23% of all malignant solid tumor patients .
MET Exon 14 Mutation is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains MET Exon 14 Mutation and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
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