Associated Genetic Biomarkers
MGMT Mutation is present in 0.46% of AACR GENIE cases, with conventional glioblastoma multiforme, melanoma, adenocarcinoma of unknown primary, bladder urothelial carcinoma, and breast invasive lobular carcinoma having the greatest prevalence .
MGMT Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains MGMT Mutation as an inclusion criterion, 1 is phase 2 (1 open).
Trials with MGMT Mutation in the inclusion eligibility criteria most commonly target breast carcinoma .
Capecitabine and targeted therapy agent are the most frequent therapies in trials with MGMT Mutation as an inclusion criteria .
Significance of MGMT Mutation in Diseases
Breast Carcinoma +
MGMT is altered in 0.05% of breast carcinoma patients with MGMT Mutation present in 5.13% of all breast carcinoma patients .
MGMT Mutation is an inclusion criterion in 1 clinical trial for breast carcinoma, of which 1 is open and 0 are closed. Of the trial that contains MGMT Mutation and breast carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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