Associated Genetic Biomarkers
MYD88 L265P is present in 0.13% of AACR GENIE cases, with diffuse large B-cell lymphoma, chronic lymphocytic leukemia, and lung adenocarcinoma having the greatest prevalence .
MYD88 L265P serves as an inclusion eligibility criterion in 2 clinical trials, of which 1 is open and 1 is closed. Of the trials that contain MYD88 L265P as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 1/phase 2 (0 open).
Trials with MYD88 L265P in the inclusion eligibility criteria most commonly target waldenstrom macroglobulinemia .
Ibrutinib and mavorixafor are the most frequent therapies in trials with MYD88 L265P as an inclusion criteria .
Significance of MYD88 L265P in Diseases
Diffuse Large B-Cell Lymphoma +
MYD88 is altered in 19.71% of diffuse large B-cell lymphoma patients with MYD88 L265P present in 13.94% of all diffuse large B-cell lymphoma patients .
MYD88 L265P is an inclusion criterion in 1 clinical trial for diffuse large B-cell lymphoma, of which 0 are open and 1 is closed. Of the trial that contains MYD88 L265P and diffuse large B-cell lymphoma as inclusion criteria, 1 is phase 1/phase 2 (0 open) .
Waldenstrom Macroglobulinemia +
MYD88 L265P is an inclusion criterion in 1 clinical trial for waldenstrom macroglobulinemia, of which 1 is open and 0 are closed. Of the trial that contains MYD88 L265P and waldenstrom macroglobulinemia as inclusion criteria, 1 is phase 1 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.