Associated Genetic Biomarkers
NOTCH1 L1574P is present in 0.02% of AACR GENIE cases, with T-cell lymphoblastic leukemia/lymphoma, salivary gland adenoid cystic carcinoma, lung adenoid cystic carcinoma, overt primary myelofibrosis, and unknown having the greatest prevalence .
NOTCH1 L1574P serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain NOTCH1 L1574P as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (1 open).
Trials with NOTCH1 L1574P in the inclusion eligibility criteria most commonly target adenoid cystic carcinoma .
Al101 and surgery are the most frequent therapies in trials with NOTCH1 L1574P as an inclusion criteria .
Significance of NOTCH1 L1574P in Diseases
Adenoid Cystic Carcinoma +
NOTCH1 is altered in 17.89% of adenoid cystic carcinoma patients with NOTCH1 L1574P present in 0.79% of all adenoid cystic carcinoma patients .
NOTCH1 L1574P is an inclusion criterion in 2 clinical trials for adenoid cystic carcinoma, of which 2 are open and 0 are closed. Of the trials that contain NOTCH1 L1574P and adenoid cystic carcinoma as inclusion criteria, 1 is phase 1 (1 open) and 1 is phase 2 (1 open) .
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