Associated Genetic Biomarkers
NOTCH1 R1598P is present in 0.03% of AACR GENIE cases, with T-cell lymphoblastic leukemia/lymphoma, breast invasive ductal carcinoma, and mature T-cell and NK-cell neoplasm having the greatest prevalence .
NOTCH1 R1598P serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains NOTCH1 R1598P as an inclusion criterion, 1 is phase 2 (1 open).
Trials with NOTCH1 R1598P in the inclusion eligibility criteria most commonly target adenoid cystic carcinoma .
Al101 is the most frequent therapy in trials with NOTCH1 R1598P as an inclusion criteria .
Significance of NOTCH1 R1598P in Diseases
Adenoid Cystic Carcinoma +
NOTCH1 is altered in 17.89% of adenoid cystic carcinoma patients .
NOTCH1 R1598P is an inclusion criterion in 1 clinical trial for adenoid cystic carcinoma, of which 1 is open and 0 are closed. Of the trial that contains NOTCH1 R1598P and adenoid cystic carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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