NRAS Codon 59 Missense
Associated Genetic Biomarkers
NRAS Codon 59 Missense is present in 0.07% of AACR GENIE cases, with acute myeloid leukemia with maturation, cutaneous melanoma, infiltrating renal pelvis and ureter urothelial carcinoma, lung adenocarcinoma, and melanoma having the greatest prevalence .
NRAS Codon 59 Missense serves as an inclusion eligibility criterion in 3 clinical trials, of which 2 are open and 1 is closed. Of the trials that contain NRAS Codon 59 Missense as an inclusion criterion, 1 is phase 1 (0 open) and 2 are phase 2 (2 open).
Trials with NRAS Codon 59 Missense in the inclusion eligibility criteria most commonly target colorectal carcinoma and colorectal adenocarcinoma .
Irinotecan, adavosertib, bevacizumab, binimetinib, and fluorouracil are the most frequent therapies in trials with NRAS Codon 59 Missense as an inclusion criteria .
Significance of NRAS Codon 59 Missense in Diseases
Colorectal Carcinoma +
NRAS is altered in 4.7% of colorectal carcinoma patients with NRAS Codon 59 Missense present in 0.01% of all colorectal carcinoma patients .
NRAS Codon 59 Missense is an inclusion criterion in 2 clinical trials for colorectal carcinoma, of which 1 is open and 1 is closed. Of the trials that contain NRAS Codon 59 Missense and colorectal carcinoma as inclusion criteria, 1 is phase 1 (0 open) and 1 is phase 2 (1 open) .
Colorectal Adenocarcinoma +
NRAS is altered in 4.72% of colorectal adenocarcinoma patients with NRAS Codon 59 Missense present in 0.01% of all colorectal adenocarcinoma patients .
NRAS Codon 59 Missense is an inclusion criterion in 1 clinical trial for colorectal adenocarcinoma, of which 1 is open and 0 are closed. Of the trial that contains NRAS Codon 59 Missense and colorectal adenocarcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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