NRAS Exon 2 Mutation
Associated Genetic Biomarkers
NRAS Exon 2 Mutation is present in 0.95% of AACR GENIE cases, with acute myeloid leukemia, colon adenocarcinoma, melanoma, colorectal adenocarcinoma, and cutaneous melanoma having the greatest prevalence .
NRAS Exon 2 Mutation serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain NRAS Exon 2 Mutation as an inclusion criterion, 1 is phase 2 (1 open) and 1 is phase 3 (1 open).
Trials with NRAS Exon 2 Mutation in the inclusion eligibility criteria most commonly target colorectal adenocarcinoma .
Folfiri regimen, bevacizumab, cetuximab, fluorouracil, and leucovorin are the most frequent therapies in trials with NRAS Exon 2 Mutation as an inclusion criteria .
Significance of NRAS Exon 2 Mutation in Diseases
Colorectal Adenocarcinoma +
NRAS is altered in 4.72% of colorectal adenocarcinoma patients with NRAS Exon 2 Mutation present in 1.85% of all colorectal adenocarcinoma patients .
NRAS Exon 2 Mutation is an inclusion criterion in 2 clinical trials for colorectal adenocarcinoma, of which 2 are open and 0 are closed. Of the trials that contain NRAS Exon 2 Mutation and colorectal adenocarcinoma as inclusion criteria, 1 is phase 2 (1 open) and 1 is phase 3 (1 open) .
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