NRAS Exon 4 Mutation
Associated Genetic Biomarkers
NRAS Exon 4 Mutation is present in 0.09% of AACR GENIE cases, with endometrial endometrioid adenocarcinoma, lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, and unknown having the greatest prevalence .
NRAS Exon 4 Mutation serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain NRAS Exon 4 Mutation as an inclusion criterion, 1 is phase 2 (1 open) and 1 is phase 3 (1 open).
Trials with NRAS Exon 4 Mutation in the inclusion eligibility criteria most commonly target colorectal adenocarcinoma .
Folfiri regimen, bevacizumab, cetuximab, fluorouracil, and leucovorin are the most frequent therapies in trials with NRAS Exon 4 Mutation as an inclusion criteria .
Significance of NRAS Exon 4 Mutation in Diseases
Colorectal Adenocarcinoma +
NRAS is altered in 4.72% of colorectal adenocarcinoma patients with NRAS Exon 4 Mutation present in 0.11% of all colorectal adenocarcinoma patients .
NRAS Exon 4 Mutation is an inclusion criterion in 2 clinical trials for colorectal adenocarcinoma, of which 2 are open and 0 are closed. Of the trials that contain NRAS Exon 4 Mutation and colorectal adenocarcinoma as inclusion criteria, 1 is phase 2 (1 open) and 1 is phase 3 (1 open) .
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