Associated Genetic Biomarkers
PALB2 Nonsense is present in 0.18% of AACR GENIE cases, with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, prostate adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence .
PALB2 Nonsense serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains PALB2 Nonsense as an inclusion criterion, 1 is phase 2 (1 open).
Trials with PALB2 Nonsense in the inclusion eligibility criteria most commonly target prostate carcinoma .
Durvalumab and olaparib are the most frequent therapies in trials with PALB2 Nonsense as an inclusion criteria .
Significance of PALB2 Nonsense in Diseases
Prostate Carcinoma +
PALB2 is altered in 1.41% of prostate carcinoma patients with PALB2 Nonsense present in 0.22% of all prostate carcinoma patients .
PALB2 Nonsense is an inclusion criterion in 1 clinical trial for prostate carcinoma, of which 1 is open and 0 are closed. Of the trial that contains PALB2 Nonsense and prostate carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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