PAM50 HER2-E subtype
PAM50 HER2-E subtype serves as an inclusion eligibility criterion in 3 clinical trials, of which 3 are open and 0 are closed. Of the trials that contain PAM50 HER2-E subtype as an inclusion criterion, 3 are phase 2 (3 open).
Trials with PAM50 HER2-E subtype in the inclusion eligibility criteria most commonly target breast carcinoma and breast adenocarcinoma .
Ado-trastuzumab emtansine, endocrine therapy, enzalutamide, neratinib, and paclitaxel are the most frequent therapies in trials with PAM50 HER2-E subtype as an inclusion criteria .
Significance of PAM50 HER2-E subtype in Diseases
Breast Carcinoma +
PAM50 HER2-E subtype is an inclusion criterion in 2 clinical trials for breast carcinoma, of which 2 are open and 0 are closed. Of the trials that contain PAM50 HER2-E subtype and breast carcinoma as inclusion criteria, 2 are phase 2 (2 open) .
Breast Adenocarcinoma +
PAM50 HER2-E subtype is an inclusion criterion in 1 clinical trial for breast adenocarcinoma, of which 1 is open and 0 are closed. Of the trial that contains PAM50 HER2-E subtype and breast adenocarcinoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.
Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.