Associated Genetic Biomarkers
PARP1 Loss is present in 0.04% of AACR GENIE cases.
PARP1 Loss serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains PARP1 Loss as an inclusion criterion, 1 is phase 2 (1 open).
Trials with PARP1 Loss in the inclusion eligibility criteria most commonly target malignant solid tumor .
Adavosertib and carboplatin are the most frequent therapies in trials with PARP1 Loss as an inclusion criteria .
Significance of PARP1 Loss in Diseases
Malignant Solid Tumor +
PARP1 is altered in 1.07% of malignant solid tumor patients with PARP1 Loss present in 0.04% of all malignant solid tumor patients .
PARP1 Loss is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains PARP1 Loss and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
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