Associated Genetic Biomarkers
PDS5B Mutation is present in 0.33% of AACR GENIE cases, with diffuse large B-cell lymphoma, not otherwise specified, acute myeloid leukemia, B-cell lymphoblastic leukemia/lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and follicular lymphoma having the greatest prevalence .
PDS5B Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains PDS5B Mutation as an inclusion criterion, 1 is phase 1 (1 open).
Trials with PDS5B Mutation in the inclusion eligibility criteria most commonly target acute myeloid leukemia and myelodysplastic syndromes .
Talazoparib is the most frequent therapy in trials with PDS5B Mutation as an inclusion criteria .
Significance of PDS5B Mutation in Diseases
Acute Myeloid Leukemia +
PDS5B is altered in 0.26% of acute myeloid leukemia patients with PDS5B Mutation present in 0.26% of all acute myeloid leukemia patients .
PDS5B Mutation is an inclusion criterion in 1 clinical trial for acute myeloid leukemia, of which 1 is open and 0 are closed. Of the trial that contains PDS5B Mutation and acute myeloid leukemia as inclusion criteria, 1 is phase 1 (1 open) .
Myelodysplastic Syndromes +
PDS5B Mutation is an inclusion criterion in 1 clinical trial for myelodysplastic syndromes, of which 1 is open and 0 are closed. Of the trial that contains PDS5B Mutation and myelodysplastic syndromes as inclusion criteria, 1 is phase 1 (1 open) .
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