Associated Genetic Biomarkers
PIK3CA H1047Y is present in 0.06% of AACR GENIE cases, with endometrial endometrioid adenocarcinoma and breast invasive ductal carcinoma having the greatest prevalence .
PIK3CA H1047Y is a predictive biomarker for use of alpelisib and fulvestrant in patients.
Of the therapies with PIK3CA H1047Y as a predictive biomarker, 2 are FDA-approved and 2 have NCCN guidelines in at least one clinical setting.
Breast carcinoma has the most therapies targeted against PIK3CA H1047Y or its related pathways .
Alpelisib + Fulvestrant +
Breast Carcinoma -
Sample must match all of the following:
|Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Metastatic (FDA, NCCN)|
|Note: Indicated for the treatment of postmenopausal women, and men, with HR-positive, HER2-negative, PIK3CA-mutated, advanced or metastatic breast cancer following progression on or after an endocrine-based regimen.|
Significance of PIK3CA H1047Y in Diseases
Breast Carcinoma +
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.