Associated Genetic Biomarkers
PIK3CA Q546L is present in 0.03% of AACR GENIE cases, with breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive lobular carcinoma, and colorectal adenocarcinoma having the greatest prevalence .
PIK3CA Q546L serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains PIK3CA Q546L as an inclusion criterion, 1 is phase 2 (1 open).
Trials with PIK3CA Q546L in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma and breast carcinoma .
Afatinib, docetaxel, durvalumab, fulvestrant, and lapatinib are the most frequent therapies in trials with PIK3CA Q546L as an inclusion criteria .
Significance of PIK3CA Q546L in Diseases
Breast Carcinoma +
PIK3CA is altered in 36.07% of breast carcinoma patients with PIK3CA Q546L present in 0.03% of all breast carcinoma patients .
PIK3CA Q546L is an inclusion criterion in 1 clinical trial for breast carcinoma, of which 1 is open and 0 are closed. Of the trial that contains PIK3CA Q546L and breast carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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