POLE c.268-c.471 Mutation
Associated Genetic Biomarkers
POLE c.268-c.471 Mutation is present in 0.08% of AACR GENIE cases, with lung adenocarcinoma, bladder urothelial carcinoma, endometrial endometrioid adenocarcinoma, adenosquamous lung carcinoma, and endometrial undifferentiated carcinoma having the greatest prevalence .
POLE c.268-c.471 Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains POLE c.268-c.471 Mutation as an inclusion criterion, 1 is phase 3 (1 open).
Trials with POLE c.268-c.471 Mutation in the inclusion eligibility criteria most commonly target colon adenocarcinoma .
Avelumab and observation are the most frequent therapies in trials with POLE c.268-c.471 Mutation as an inclusion criteria .
Significance of POLE c.268-c.471 Mutation in Diseases
Colon Adenocarcinoma +
POLE is altered in 6.24% of colon adenocarcinoma patients with POLE c.268-c.471 Mutation present in 0.03% of all colon adenocarcinoma patients .
POLE c.268-c.471 Mutation is an inclusion criterion in 1 clinical trial for colon adenocarcinoma, of which 1 is open and 0 are closed. Of the trial that contains POLE c.268-c.471 Mutation and colon adenocarcinoma as inclusion criteria, 1 is phase 3 (1 open) .
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