Associated Genetic Biomarkers
RAD21 Loss is present in 0.04% of AACR GENIE cases, with bladder urothelial carcinoma, conventional glioblastoma multiforme, endometrial serous adenocarcinoma, adenocarcinoma of unknown primary, and cancer of unknown primary having the greatest prevalence .
RAD21 Loss serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains RAD21 Loss as an inclusion criterion, 1 is phase 1 (1 open).
Trials with RAD21 Loss in the inclusion eligibility criteria most commonly target acute myeloid leukemia and myelodysplastic syndromes .
Talazoparib is the most frequent therapy in trials with RAD21 Loss as an inclusion criteria .
Significance of RAD21 Loss in Diseases
Acute Myeloid Leukemia +
RAD21 is altered in 2.22% of acute myeloid leukemia patients .
RAD21 Loss is an inclusion criterion in 1 clinical trial for acute myeloid leukemia, of which 1 is open and 0 are closed. Of the trial that contains RAD21 Loss and acute myeloid leukemia as inclusion criteria, 1 is phase 1 (1 open) .
Myelodysplastic Syndromes +
RAD21 is altered in 0.67% of myelodysplastic syndromes patients .
RAD21 Loss is an inclusion criterion in 1 clinical trial for myelodysplastic syndromes, of which 1 is open and 0 are closed. Of the trial that contains RAD21 Loss and myelodysplastic syndromes as inclusion criteria, 1 is phase 1 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.
Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.