Associated Genetic Biomarkers
RAD21 Mutation is present in 0.86% of AACR GENIE cases, with colon adenocarcinoma, lung adenocarcinoma, acute myeloid leukemia, breast invasive ductal carcinoma, and bladder urothelial carcinoma having the greatest prevalence .
RAD21 Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains RAD21 Mutation as an inclusion criterion, 1 is phase 1 (1 open).
Trials with RAD21 Mutation in the inclusion eligibility criteria most commonly target acute myeloid leukemia and myelodysplastic syndromes .
Talazoparib is the most frequent therapy in trials with RAD21 Mutation as an inclusion criteria .
Significance of RAD21 Mutation in Diseases
Acute Myeloid Leukemia +
RAD21 is altered in 2.65% of acute myeloid leukemia patients with RAD21 Mutation present in 2.65% of all acute myeloid leukemia patients .
RAD21 Mutation is an inclusion criterion in 1 clinical trial for acute myeloid leukemia, of which 1 is open and 0 are closed. Of the trial that contains RAD21 Mutation and acute myeloid leukemia as inclusion criteria, 1 is phase 1 (1 open) .
Myelodysplastic Syndromes +
RAD21 Mutation is an inclusion criterion in 1 clinical trial for myelodysplastic syndromes, of which 1 is open and 0 are closed. Of the trial that contains RAD21 Mutation and myelodysplastic syndromes as inclusion criteria, 1 is phase 1 (1 open) .
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