Associated Genetic Biomarkers
RAD51D Nonsense is present in 0.01% of AACR GENIE cases.
RAD51D Nonsense serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains RAD51D Nonsense as an inclusion criterion, 1 is phase 2 (1 open).
Trials with RAD51D Nonsense in the inclusion eligibility criteria most commonly target prostate carcinoma .
Durvalumab and olaparib are the most frequent therapies in trials with RAD51D Nonsense as an inclusion criteria .
Significance of RAD51D Nonsense in Diseases
Prostate Carcinoma +
RAD51D is altered in 0.24% of prostate carcinoma patients .
RAD51D Nonsense is an inclusion criterion in 1 clinical trial for prostate carcinoma, of which 1 is open and 0 are closed. Of the trial that contains RAD51D Nonsense and prostate carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.
Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.