Associated Genetic Biomarkers
RAD52 Loss is present in 0.04% of AACR GENIE cases, with invasive breast carcinoma, lung adenocarcinoma, conventional glioblastoma multiforme, cutaneous melanoma, and diffuse large B-cell lymphoma, not otherwise specified having the greatest prevalence .
RAD52 Loss serves as an inclusion eligibility criterion in 2 clinical trials, of which 1 is open and 1 is closed. Of the trials that contain RAD52 Loss as an inclusion criterion, 2 are phase 2 (1 open).
Trials with RAD52 Loss in the inclusion eligibility criteria most commonly target small cell lung carcinoma and urothelial carcinoma .
Olaparib is the most frequent therapy in trials with RAD52 Loss as an inclusion criteria .
Significance of RAD52 Loss in Diseases
Urothelial Carcinoma +
RAD52 is altered in 0.96% of urothelial carcinoma patients with RAD52 Loss present in 0.06% of all urothelial carcinoma patients .
RAD52 Loss is an inclusion criterion in 1 clinical trial for urothelial carcinoma, of which 1 is open and 0 are closed. Of the trial that contains RAD52 Loss and urothelial carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Small Cell Lung Carcinoma +
RAD52 is altered in 1.43% of small cell lung carcinoma patients .
RAD52 Loss is an inclusion criterion in 1 clinical trial for small cell lung carcinoma, of which 0 are open and 1 is closed. Of the trial that contains RAD52 Loss and small cell lung carcinoma as inclusion criteria, 1 is phase 2 (0 open) .
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