Associated Genetic Biomarkers
RB1 Nonsense is present in 1.39% of AACR GENIE cases, with lung adenocarcinoma, bladder urothelial carcinoma, small cell lung carcinoma, conventional glioblastoma multiforme, and breast invasive ductal carcinoma having the greatest prevalence .
RB1 Nonsense serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains RB1 Nonsense as an inclusion criterion, 1 is phase 2 (1 open).
Trials with RB1 Nonsense in the inclusion eligibility criteria most commonly target endometrial endometrioid adenocarcinoma, glioblastoma, leiomyosarcoma, non-small cell lung carcinoma, and prostate adenocarcinoma .
Abemaciclib, apalutamide, bevacizumab, cetrelimab, and everolimus are the most frequent therapies in trials with RB1 Nonsense as an inclusion criteria .
Significance of RB1 Nonsense in Diseases
Prostate Adenocarcinoma +
RB1 is altered in 5.19% of prostate adenocarcinoma patients with RB1 Nonsense present in 0.86% of all prostate adenocarcinoma patients .
RB1 Nonsense is an inclusion criterion in 1 clinical trial for prostate adenocarcinoma, of which 1 is open and 0 are closed. Of the trial that contains RB1 Nonsense and prostate adenocarcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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