Associated Genetic Biomarkers
RECQL4 Mutation is present in 2.31% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence .
RECQL4 Mutation serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain RECQL4 Mutation as an inclusion criterion, 2 are phase 2 (2 open).
Trials with RECQL4 Mutation in the inclusion eligibility criteria most commonly target small cell lung carcinoma and urothelial carcinoma .
Olaparib is the most frequent therapy in trials with RECQL4 Mutation as an inclusion criteria .
Significance of RECQL4 Mutation in Diseases
Urothelial Carcinoma +
RECQL4 is altered in 3.61% of urothelial carcinoma patients with RECQL4 Mutation present in 3.26% of all urothelial carcinoma patients .
RECQL4 Mutation is an inclusion criterion in 1 clinical trial for urothelial carcinoma, of which 1 is open and 0 are closed. Of the trial that contains RECQL4 Mutation and urothelial carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Small Cell Lung Carcinoma +
RECQL4 is altered in 3.59% of small cell lung carcinoma patients with RECQL4 Mutation present in 2.29% of all small cell lung carcinoma patients .
RECQL4 Mutation is an inclusion criterion in 1 clinical trial for small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains RECQL4 Mutation and small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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