ROS1 Activating Mutation
Associated Genetic Biomarkers
ROS1 Activating Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ROS1 Activating Mutation as an inclusion criterion, 1 is phase 1 (1 open).
Trials with ROS1 Activating Mutation in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma .
Sapanisertib and telaglenastat are the most frequent therapies in trials with ROS1 Activating Mutation as an inclusion criteria .
Significance of ROS1 Activating Mutation in Diseases
Non-Small Cell Lung Carcinoma +
ROS1 is altered in 4.69% of non-small cell lung carcinoma patients .
ROS1 Activating Mutation is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ROS1 Activating Mutation and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.
Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.
4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.