Associated Genetic Biomarkers
SMC1A Mutation is present in 1.25% of AACR GENIE cases, with lung adenocarcinoma, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, conventional glioblastoma multiforme, and bladder urothelial carcinoma having the greatest prevalence .
SMC1A Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains SMC1A Mutation as an inclusion criterion, 1 is phase 1 (1 open).
Trials with SMC1A Mutation in the inclusion eligibility criteria most commonly target acute myeloid leukemia and myelodysplastic syndromes .
Talazoparib is the most frequent therapy in trials with SMC1A Mutation as an inclusion criteria .
Significance of SMC1A Mutation in Diseases
Acute Myeloid Leukemia +
SMC1A is altered in 0.68% of acute myeloid leukemia patients with SMC1A Mutation present in 0.68% of all acute myeloid leukemia patients .
SMC1A Mutation is an inclusion criterion in 1 clinical trial for acute myeloid leukemia, of which 1 is open and 0 are closed. Of the trial that contains SMC1A Mutation and acute myeloid leukemia as inclusion criteria, 1 is phase 1 (1 open) .
Myelodysplastic Syndromes +
SMC1A is altered in 0.35% of myelodysplastic syndromes patients with SMC1A Mutation present in 0.23% of all myelodysplastic syndromes patients .
SMC1A Mutation is an inclusion criterion in 1 clinical trial for myelodysplastic syndromes, of which 1 is open and 0 are closed. Of the trial that contains SMC1A Mutation and myelodysplastic syndromes as inclusion criteria, 1 is phase 1 (1 open) .
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