Associated Genetic Biomarkers
SMC3 Mutation is present in 1.11% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, bladder urothelial carcinoma, and melanoma having the greatest prevalence .
SMC3 Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains SMC3 Mutation as an inclusion criterion, 1 is phase 1 (1 open).
Trials with SMC3 Mutation in the inclusion eligibility criteria most commonly target acute myeloid leukemia and myelodysplastic syndromes .
Talazoparib is the most frequent therapy in trials with SMC3 Mutation as an inclusion criteria .
Significance of SMC3 Mutation in Diseases
Acute Myeloid Leukemia +
SMC3 is altered in 0.76% of acute myeloid leukemia patients with SMC3 Mutation present in 0.71% of all acute myeloid leukemia patients .
SMC3 Mutation is an inclusion criterion in 1 clinical trial for acute myeloid leukemia, of which 1 is open and 0 are closed. Of the trial that contains SMC3 Mutation and acute myeloid leukemia as inclusion criteria, 1 is phase 1 (1 open) .
Myelodysplastic Syndromes +
SMC3 is altered in 0.56% of myelodysplastic syndromes patients with SMC3 Mutation present in 0.45% of all myelodysplastic syndromes patients .
SMC3 Mutation is an inclusion criterion in 1 clinical trial for myelodysplastic syndromes, of which 1 is open and 0 are closed. Of the trial that contains SMC3 Mutation and myelodysplastic syndromes as inclusion criteria, 1 is phase 1 (1 open) .
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