Associated Genetic Biomarkers
STAT5B Loss is present in 0.07% of AACR GENIE cases, with prostate adenocarcinoma, breast invasive lobular carcinoma, high grade ovarian serous adenocarcinoma, breast invasive ductal carcinoma, and leiomyosarcoma having the greatest prevalence .
STAT5B Loss serves as an inclusion eligibility criterion in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains STAT5B Loss as an inclusion criterion, 1 is phase 2 (0 open).
Trials with STAT5B Loss in the inclusion eligibility criteria most commonly target malignant solid tumor .
Irinotecan and sorafenib are the most frequent therapies in trials with STAT5B Loss as an inclusion criteria .
Significance of STAT5B Loss in Diseases
Malignant Solid Tumor +
STAT5B is altered in 0.87% of malignant solid tumor patients with STAT5B Loss present in 0.04% of all malignant solid tumor patients .
STAT5B Loss is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 0 are open and 1 is closed. Of the trial that contains STAT5B Loss and malignant solid tumor as inclusion criteria, 1 is phase 2 (0 open) .
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