Associated Genetic Biomarkers
TERT Loss is present in 0.09% of AACR GENIE cases, with anaplastic astrocytoma, anaplastic oligoastrocytoma, astrocytoma, breast invasive ductal carcinoma, and conventional glioblastoma multiforme having the greatest prevalence .
TERT Loss serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains TERT Loss as an inclusion criterion, 1 is phase 2 (1 open).
Trials with TERT Loss in the inclusion eligibility criteria most commonly target glioblastoma and glioblastoma, IDH-wildtype .
Dendritic cell vaccine and placebo are the most frequent therapies in trials with TERT Loss as an inclusion criteria .
Significance of TERT Loss in Diseases
TERT is altered in 4.44% of glioblastoma patients with TERT Loss present in 0.21% of all glioblastoma patients .
TERT Loss is an inclusion criterion in 1 clinical trial for glioblastoma, of which 1 is open and 0 are closed. Of the trial that contains TERT Loss and glioblastoma as inclusion criteria, 1 is phase 2 (1 open) .
Glioblastoma, IDH-Wildtype +
TERT is altered in 1.96% of glioblastoma, IDH-wildtype patients .
TERT Loss is an inclusion criterion in 1 clinical trial for glioblastoma, IDH-wildtype, of which 1 is open and 0 are closed. Of the trial that contains TERT Loss and glioblastoma, IDH-wildtype as inclusion criteria, 1 is phase 2 (1 open) .
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